B.S., Chemistry, Southampton College of Long Island University
Ph.D., Biochemistry, Stanford University
My laboratory is interested in studying protein polymerizing systems. Two general areas that we are exploring are: (1) polymerizing systems as models for protein aggregative disease; and (2) polymerizing systems for biomaterials design.
We are interested in developing a detailed understanding of the molecular and cellular mechanisms involved in protein aggregation and consequent neurodegeneration, such a seen in Huntington's Disease, Amyotropic Lateral Sclerosis, and Fronto-Temporal Dementia. We take advantage of biochemical and microscopy approaches to study in vitro and in vivo protein aggregation, using D. melanogaster and C. elegans transgenic model systemss. Such techniques include confocal and fluorescence microscopies, and various gel electrophoresis techniques (Western, SDD-AGE).