Amy will be working remotely and on campus on and off throughout the Fall of 2020. To schecule an appoinment, please email her at email@example.com. Thank you!
The Cooke lab wants to understand the mechanisms and genomics of RNA control, and its roles in biology and disease. All biological processes rely on precise control of the genetic material. The control of RNA, the immediate product of DNA, is vital. RNA-binding proteins (RBPs) dictate which mRNAs are regulated, and how, when and where that regulation occurs within a cell. The roles of RBPs and RNA in biology are incontrovertible: their dysfunctions cause disease, including cancer, epilepsy and obesity. The challenge now is to understand their molecular mechanisms and pathways to understand how they underlie key events in biology and disease.
The richness of the problem lies in the staggeringly large number of ways RBPs can exert their control, and the revelation that their effects can vary from RNA to RNA, cell to cell, in health vs. disease. We address these questions using a range of approaches, from molecular biology to biochemistry to genomics and mass spectrometry.