The Core Facility includes a Beckman-Coulter ProteomeLab XLA analytical ultracentrifuge, equipped with absorbance optics that can collect data in the 200-800 nm range. Speeds of 3,000-50,000 rpm can be run, and the instrument may be operated at temperatures of 4°C-40°C.

This instrument is used to study the hydrodynamic properties of macromolecules in solution, such as size and shape. In addition, oligomeric states and binding affinities of macromolecular interactions can be readily determined. Two common methods that are used are sedimentation velocity and sedimentation equilibrium.

The instrument is under the direction of Dr. Fairman and operated by Mr. Kokona. You may contact them using the form below with queries or questions about the use of the instrument, information about collaborative arrangements, and fee-for-service work.  User training is available upon request. Sample requirements and information regarding data analysis performed will be added shortly.