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Campus | Haverford |
Semester | Spring 2023 |
Registration ID | BIOLH457H001 |
Course Title | Advanced Topics in Protein Science |
Credit | 0.50 |
Department | Neuroscience |
Instructor | Fairman,Robert |
Times and Days | MW 10:00am-11:30am
|
Room Location | SHA113 |
Additional Course Info | Class Number: 2179 In the last decade great strides have been made in identifying protein misfolding and aggregation in a wide variety of debilitating human diseases. It is now becoming clear that many dementias and other signs of “old age” can now be attributed to these diseases, leading to a decrease in the quality of life. Thus, approaches to treat these diseases are of paramount importance for quality of life issues. In order to develop treatments, a molecular understanding of these diseases is critical. The underlying biophysical basis for protein misfolding and aggregation is now largely understood and involves a common structural motif called the cross-b-sheet fibril. This course will focus on a set of diseases for which we now know quite a lot about the chemistry, molecular biology, and cell biology that underlies the misfolding behavior of the protein in question. We will look at Alzheimer’s disease, prion infectious disease, Huntington’s disease, Parkinson’s disease, and ALS or Lou Gehrig’s disease. While the course will focus on the primary literature that discusses the protein aggregation problem, other disciplinary areas such as genetics, cell biology, animal model systems, and clinical biology may be introduced as appropriate.; Enrollment Limit: 15 Natural Science, C: Physical and Natural Processes (; Hav: NA, C) |
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