Chemistry 351, Bioinorganic Chemistry, taught by Rob Scarrow, Haverford College

Reading questions from Bertini, Gray, Stiefel and Valentine "Biological Inorganic Chemistry: Structure and Reactivity", Sausalito, University Science Books, 2007.

See also page with Errata from the book

Problems

Reading Assignment

Theme

A1-6

Chapter I and II through the end of section II.3

Bioavailability of the elements

A7-9

Tutorial 1

Basic Protein Biochemistry

B1-5

Tutorial 2

Basic Coordination Chemistry

B6-12

Chapter III

Metalloproteins

C1-6

Section IX.1

Metal-dependent lyases and hydrolases

C7, D8

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Introduction to using RCSB Protein Database

D1-6

Section XIV.3

Calcium and calcium binding proteins

D7-D8

Section XIV.2

Zinc Fingers

E1-4

Section XI.1

Reactivity of O2

E5-10

Section XI.4.x (x=1,2,4)

Dioxygen carriers

F1-7

Section XI.2

Superoxide Dismutase and Reductases

Fb1-5

Section XI.3

Peroxidases

G1-5

Section XI.5

Monooxygenases

H1-5

Section XI.6

Cytochrome c oxidase

J1-7

Section XII.6

Molybdenum enzymes

K1-6

Chapter V

Metal ion transport and storage

K7-8

Section VIII.1

Transferrin

L1-2

Section VIII.2

Ferritin

L3-8

Section VIII.3

Siderophores

M1-8

Sections VII.1, VII.2.1, VII.2.2 and VII.3.2

Metals in Medicine

N1-6

Supplemental reading: Barkay, T.; Miller, S. M.; Summers, A. O. FEMS Microbiol. Rev. 2003, 27, 355-384.

Bacterial Mercury Resistance

N7-9

Supplemental reading: Godwin, H. A. Curr. Opinion Chem. Biol. 2001, 5, 223-227.

Lead toxicity

O1-5

Chapter IV

Cofactors (incl. hemes, FeS clusters, B12)

O6-10

Section X.1

Electron transfer proteins

P 1-6 Section XIII.2 Cobalamins and B12-dependent enzymes
Q 1-5 Section XIV.1 Metalloregulation

These questions are authored by Rob Scarrow, Haverford College and may be reproduced and/or modified for use in teaching or learning about bioinorganic chemistry. I welcome suggestions for improvements and/or contributed problem sets for other sections of the Bertin et al. book.

 

Last updated: April 24, 2013
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