Natural Sciences: Chemistry, 2010-11
The program in chemistry is designed to meet the needs of students who are pursuing chemistry either for a variety of pre-professional reasons or to increase their knowledge of the natural sciences. Therefore, Haverford has a chemistry major program that provides preparation for careers in science, medicine, law, business, K-12 education as well as a number of other professions.
The major program recognizes that chemistry as a discipline is a core science but is also intertwined in a number of other fields, including physics, biology and math/computer science. In fact, some of the most exciting areas in science today are found in the interdisciplinary fields of chemical physics, chemical biology, theoretical/computational chemistry, environmental studies and materials science. The chemistry major allows the student flexibility in designing a program that can be directed toward such interdisciplinary areas or to one of the more traditional areas of organic, physical, or inorganic chemistry. In addition, the chemistry department is one of the sponsor departments of the concentrations in scientific computing and biochemistry and biophysics.
This academic year is a transitional one for the Chemistry Department as we inaugurate four new courses for our first year program. Students have four possible entry points into the program. The particular entry point or placement depends on the level of preparation of the individual student and is determined by the combination of results from a placement questionnaire, secondary school records, scores from standardized and advanced placement tests, and individual consultation. All four starting points can result in the completion of the chemistry major program. For the first entry point, no previous chemistry experience is required and students enter the first year of the general chemistry sequence with a Foundations course (Chem 110)followed by the regular introductory courses (Chem 111 and Chem 112). The second entry point is for those students with a typical good high school chemistry preparation. They will take two semesters of introductory course work (Chem 111 and 112). The third entry point is for students with an excellent high school chemistry background, who can omit Chem 111 and take only Chem 112 along with a new half credit investigative lab course, Chem 115, which introduces spectroscopy. These advanced first-year students have an extra course slot available in their first semester that might be used for a mathematics and/or a physics course. All of these students will continue the following year with a new organic sequence of courses(starting in academic year 2011-2012). Finally, the fourth option available to a few students with an excellent high school chemistry background is to take organic chemistry (220, 221) in the first year, continuing with junior-level chemistry in the sophomore year.
All students as seniors are required to participate in a research program for advanced course credit, and first to third year students with strong interests in Chemistry are able to get involved with research throughout 260 level courses. This research experience nurtures talents and abilities, encourages independent problem solving and builds on concepts and principles discussed in prior formal class work. It also can help the student define choices for careers after graduation. Summer research experience is particularly encouraged. The summer experience provides a background of focused work that can greatly enrich the senior thesis research experience. In recent years, fifteen to twenty students per summer have received stipends to participate in research in the chemistry department.
Chemistry majors wishing to study abroad during the junior year should confer with the faculty advisor and should plan to take at least one chemistry course per semester at the foreign institution. The chemistry department has currently approved international study abroad programs at Oxford University (England), University College London (England), University of Melbourne (Australia) and University of Aberdeen (Scotland). Chemistry majors have also satisfied major requirements using courses from domestic programs such as the Semester in Environmental Science at the Marine Biological Laboratory in Woods Hole, Massachusetts.
John Farnum Professor of Chemistry Colin MacKay, Emeritus
Professor Claude E. Wintner, Emeritus
Professor Karin Åkerfeldt
Professor Terry Newirth, Chairperson
Professor Robert Scarrow
Associate Professor Frances Rose Blase (on leave 2010-2011)
Assistant Professor Casey Londergan
Assistant Professor Alexander Norquis (on leave 2010-2011)
Assistant Professor Joshua Schrier
Assistant Professor Helen White
Visiting Professor Charles Lerman
Visiting Professor Lennart Sjölin
General Chemistry Laboratory Instructor Dennis Collin
Organic Chemistry Laboratory Instructor Michael J. Kukla
Each student confers with the major advisor to plan a program that takes into account specific interests and career aims. The major requirements have been designed to meet the educational needs of students interested in careers in chemistry, biochemistry, engineering, medicine, K-12 education, business, law, and other professions. An American Chemical Society (ACS) certified major requires additional coursework and is recommended for students interested in pursuing graduate study in science and engineering, or who wish to directly enter the job market in a chemistry related field after graduation.
The core required courses are: Chemistry 111 or 115, 112, 220, 221, 301, 302, 304 or 305, at least one semester of 380 or 36x (research tutorials), one semester of inorganic chemistry (two half-semester courses: Chemistry 320 and one of 351, 353 or 354) and Chemistry 391 (senior seminar). Chemistry majors must also complete one semester of additional advanced chemistry courses numbered 304-358; one semester of mathematics courses numbered 114 (calculus II) or higher; and either introductory physics (Physics 101/102 or 105/106) or both semesters of Biology 200.
Chemistry Major with Biochemistry Concentration
Biochemistry concentrators are allowed to substitute either semester of Biology 300 for Chemistry 302. (Chemistry 301 (Superlab I) is required for all chemistry majors and cannot be replaced.) Concentrators also must take one semester of an advanced biology course (see the Biochemistry and Biophysics section of this catalog for a current list of advanced Biology courses), and two half semester advanced chemistry courses with a biological emphasis. These include Chem 351 (0.5 semester, bioinorganic), Chem 352 (0.5 semester, biophysical) or Chem 357 (0.5 semester, bioorganic). Biology 200a, 200b, Physics 101/102 or 105/106 are required for biochemistry concentrators.
Chemistry Major with Scientific Computing Concentration
See the Computer Science page for details on this concentration. In the chemistry department, courses which can contribute to this concentration are Chem 304, Chem 305, and Chem 362; students are also encouraged to enroll in Chem B322 when offered. The department coordinator for this concentration is Joshua Schrier.
ACS-Certified Chemistry Major
In order to receive ACS-certification, students must satisfy all of the major requirements (with or without a biochemistry concentration) above and as an additional course must complete the second semester of physical chemistry (304 or 305). The following requirements also apply for ACS-certification and may be met with the same courses used to meet major requirements: Physics 101/102 or 105/106 and at least one semester of biochemistry. This last requirement may be satisfied by Biology 200 (second semester), by Bryn Mawr Chemistry 242, or by two half-semester courses of Chemistry 351, 352, or 357.
The required courses are: Chemistry 111 or 115,112, 220, 221, 304 or 305, and one semester of advanced chemistry chosen from courses numbered between 301 and 369. Students who begin by placement in Chemistry 220 must take an additional (fifth) chemistry course credit with an analytical or physical chemistry laboratory component (such as Chemistry 301 or 302, or Bryn Mawr Chemistry 251 and 252). At least three of the courses taken for the chemistry minor must be taken at Haverford College. The senior seminar (Chemistry 391) is not required, but attendance at seminars, including the Philips Visitor Series in Chemistry, is strongly recommended.
All students who participate in senior research will be considered for departmental honors. Successful honors candidates will be expected to do superior work in major courses and to complete a research problem at a level superior both in quality and quantity of effort to that expected in normal course work.
110 Fundamentals of Chemistry NA/QU
Topics include dimensional analysis, atomic structure, nuclear chemistry, Lewis structures, behavior of gases, stoichiometry in solid, liquid and gas phase reactions, thermochemistry, and intermolecular forces. This course does not count toward the chemistry major but will serve as a foundation to Chemistry 111 (Structure and Bonding) and Chemistry 112 (Dynamics) which are required for the major. Prerequisite: No high school chemistry or placement by department. Does not count toward the major. Typically offered every Fall.
111 Chemical Structure and Bonding NA
Structure and bonding in molecules starting from nuclear and electronic structure of atoms. This course introduces the theories of chemical bonding that rationalize and predict the structures and bulk properties of molecules and materials. It also introduces modern instrumental and computational methods used to study chemical structure and bonding. Prerequisite: High school Chemistry course and placement by the Department. Three-hour lab meets every other week. Typically offered every Semester.
112 Chemical Dynamics NA/QU
An introduction to chemical thermodynamics, equilibrium, electrochemistry and kinetics. Microscopic properties are used to develop basic chemical concepts of energy, enthalpy, entropy, and the Gibbs Energy, and their applications to thermochemistry, equilibria, and electrochemistry. Chemical kinetics, reaction mechanisms, and applications to chemical problems are also discussed. 3 Hour Lab, meets every other week. Prerequisite: High school Chemistry and Placement by the Department. Three-hour lab meets every other week. Typically offered every Semester.
115 Chemical Structure Inquiry Lab NA
Students will become acquainted with modern methods of chemical structure analysis as they discover the identity of unknown chemical compounds via self-proposed experiments. Prerequisite: Placement by the department. Students placed in this course generally have a 4, or more frequently a 5, on the Chem AP as well as high SAT scores. Our placement in this lab course would be similar to our current placement in our advanced one semester general chemistry course, Chem 105. Students placed in this course would also be required to take our new Chemical Dynamics course before progressing to the 200 level courses. Typically offered every Fall.
151 Case Studies in Chemistry NA
This course is intended for non-science majors. It will explore aspects of the structure & properties of atoms and molecules, and how they account for observable phenomena within the topics of light, radiation, and color. Illustrations will be drawn from various fields of science and everyday life. Concepts will be developed both qualitatively and quantitatively. Not open to students with prior college-level chemistry. Does not count toward the major.
154 Nanotechnology NA
Three lectures. Directed to non-science majors. Concepts and current understanding in synthesis and practical application of natural and man-made devices on the nanoscale. Topics include popular conception of nanodevices, current research implementation of nanoscale devices, biological self-assembly, and devices based on biomolecular media. Does not count toward the major. Offered occasionally.
220 Organic Chemistry I: Introduction to Organic Chemistry NA
Three lectures, one required recitation, and one laboratory period. The basic structural, mechanistic, and synthetic concepts of organic chemistry, and the properties of the common organic functional groups, are surveyed. Students must be free to attend one afternoon of lab AND one recitation time. Prerequisite: Grade of 2.0 in Chem 101b or 105b, or placement by Dept. Typically offered every Fall.
221 Organic Chemistry II: Topics in Organic Chemistry NA
Three lectures, one required recitation, and one laboratory period. Topics in stereochemistry, reaction mechanisms, biochemistry and natural-products chemistry, building on the fundamentals developed in Chemistry 220. Students must be free to attend one afternoon of lab AND one recitation time. Prerequisite: Grade of 2.0 in Chemistry 220a. Typically offered every Spring.
263 Research Tutorial in Organic Chemistry NA
K.Akerfeldt, F.Blase, T.Newirth
One-half credit course for the year designed for students interested in the chemistry research experience in synthetic organic chemistry and physical-organic chemistry. Topics include total synthesis of biologically significant molecules, new methods of enantioselective synthesis, and the study of organic reaction mechanisms. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.
301 Lab in Chemical Structure and Reactivity NA
Two lectures and two laboratory periods. An introduction to the methods of research in chemistry. Inorganic, organic, physical chemistry, computational chemistry, and biochemical concepts are integrated in a broad laboratory study of structure and its relationship to chemical reactivity. Physical methods are used in studies of organic, inorganic, and biochemical reactions. Chemical synthesis and the modern methods of computation and instrumental analytical chemistry are particularly stressed. Prerequisite: Chem 221b (Co-requisite: 304a). Typically offered every Fall.
302 Lab in Chemical Structure and Reactivity NA
Two lectures and two laboratory periods. An introduction to the methods of research in chemistry. Inorganic, organic, physical chemistry, and biochemical concepts are integrated in a broad laboratory study of structure and its relationship to chemical reactivity. Physical methods are used in studies of organic, inorganic, and biochemical reactions. Chemical synthesis and the modern methods of instrumental analytical chemistry are particularly stressed. Instruments such as lasers, the 300 MHz NMR spectrometer, and the mass spectrometer combined with either gas or liquid chromatography are used by students, with faculty supervision. Prerequisite: Chem 221b and 304a. Typically offered every Spring.
304 Statistical Thermodynamics and Kinetics NA/QU
Three lectures. A quantitative approach to the description and prediction of behavior in chemical systems. Topics to be covered include: introductory quantum mechanics and energy in molecules, statistical mechanics and energy partitioning, thermodynamics of molecules and larger systems, physical and chemical equilibrium, and chemical kinetics. Systems of interest range from single molecules to complicated condensed-phase macromolecular assemblies; specific experimental examples of single-molecule observation, phase changes in lipids and liquid crystals, and observations of protein folding will be discussed in the context of the course material. Prerequisite: One semester of Math 114 or 115, Math 121 or 216 is highly recommended. Typically offered every Fall.
305 Quantum Chemistry NA
Two lectures. The quantum theory of atoms and molecules as applied to problems in molecular structure, computational chemistry, and basic spectroscopic techniques. Emphasis on computer-based solutions and visualization. Prerequisite: Math 121 or 216. Typically offered every Spring.
320 Concepts of Inorganic Chemistry NA
Three lectures for one-half semester (one-half course credit). An introduction to structure and reactivity of inorganic molecules and materials. Topics include: theories of chemical bonding, symmetries of molecules and solid state materials, acid-base, oxidation-reduction reactions, and structures and nomenclature of coordination complexes. Prerequisite: Chemistry 304a. Typically offered every Spring.
340 Molecular Spectroscopy NA
Two lectures for one-half semester (one-half course credit). Quantum mechanical description of current techniques in the spectroscopy of molecules. Prerequisite: Chemistry 305 or Physics 214 or consent of instructor. Typically offered in alternate years.
351 Bioinorganic Chemistry NA
Three lectures for one-half semester (one-half course credit). Biological cells require metals such as zinc, iron, copper, manganese, and molybdenum; metal-binding abilities of various functional groups within proteins and nucleic acids, metal-based reactivity involved in reaction mechanisms of specific metalloenzymes, and medically-relevant topics such as bioaccumulation and storage of metal ions, the toxicity of heavy metals, and use of metal-containing drugs in treating disease will be discussed. Prerequisite: Chem 221 or 304 or consent. Students should have completed 320g or a Biol course involving protein structure. Typically offered every Spring.
352 Topics in Biophysical Chemistry NA
Prerequisite: Chemistry 304a. Offered occasionally.
353 Topics in Materials Science NA
Three lectures for one-half semester (one-half course credit). This course will focus on the structure-property relationship central to the study of materials with specific functions. Structural studies will include bonding, order/disorder, and non-stoichiometry in crystalline and non-crystalline solids. Optical, magnetic and electronic properties will be discussed in the context of non-linear optical materials, ferroelectric and magnetoresistant materials, as well as superconductors and semiconductors. Prerequisite: Chem 304 or Phys 214 & Chem 101b or Chem 105b. Typically offered every Spring.
354 Solid State Chemistry NA
Three lectures for one-half semester (one-half course credit). An examination of the reactivity of solids. Synthetic techniques and structural analyses will be emphasized. Prerequisite: Chem 304 or Phys 214 & Chem 101 or 105. Offered occasionally.
355 Topics in Advanced Organic Chemistry NA
Three lectures for one-half semester (one-half course credit). Variable content, depending on the interests of students and faculty. Topics are selected in consultation with students electing the course. Previous topics have been modern synthetic methods, asymmetric synthesis, natural product chemistry, biosynthesis, chemistry of coenzymes, combinatorial approaches to synthesis, free radical chemistry, organometallic chemistry. Topics selected differ from those selected for 357 in the previous year. Prerequisite: Chemistry 221. Offered occasionally.
357 Topics in Bioorganic Chemistry NA
Prerequisite: Chemistry 221b.
358 Environmental Chemistry NA
Three lectures for one-half semester (one-half course credit). This course will examine chemical processes that occur in natural waters, soils and the atmosphere. Specific topics will be chosen with input from enrolled students, who will be expected to share in discussion leadership. Prerequisite: Chem 304a or equiv. or permission. Typically offered in alternate years.
380 Independent Research in Chemistry NA
This course is designed for chemistry majors who want to pursue a library research experience. Students will work closely with a faculty member on a topic in the current chemical literature to prepare a thesis paper. Prerequisite: Chemistry 221 and Chemistry 304.
391 Departmental Seminar NA
One meeting per week throughout the year (one-half course credit). Presentation and discussion of current research topics in the various areas of chemistry by faculty, students and outside speakers.
480 Independent Study NA
RESEARCH TUTORIALSStudents may register for a research tutorial in an area of active faculty research. In these tutorials the student attempts to define and solve a research problem under the close supervision of a faculty member.
363 Research Tutorial in Organic Chemistry NA
Directed research in synthetic organic chemistry, and physical-organic chemistry. Topics include total synthesis of biologically significant molecules, new methods of enantioselective synthesis and the study of organic reaction mechanisms. Prerequisite: Consent.
261 Research Tutorial in Physical Chemistry NA
One-half credit course for the year designed for students interested in the chemistry research experience in physical chemistry, condensed phase chemical physics, and biophysical chemistry, with emphasis on spectroscopic studies of peptides and proteins. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.
262 Research Tutorial in Theoretical Chemistry NA
One-half credit course for the year designed for students interested in the chemistry research experience in theoretical physical chemistry, with emphasis on methods for prediction of optical, electronic, and mechanical properties of organic and inorganic semiconductor nanostructures. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.
264 Research Tutorial in Bioorganic Chemistry NA
One-half credit course for the year designed for students interested in the chemistry research experience in protein structure-function relationship studies and the design and synthesis of a broad range of peptides, proteins and biologically inspired novel materials. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.
265 Research Tutorial in Bioinorganic Chemistry NA
One-half credit course for the year designed for students interested in the chemistry research experience in spectroscopic and kinetic studies of metalloproteins and inorganic coordination compounds. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.
268 Research Tutorial in Environmental Chemistry NA
One-half credit course for the year designed for students interested in the chemistry research experience in the field of biogeochemistry, a multidisciplinary approach focused at understanding the chemical composition and processes of Earth's biosphere. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.
269 Research Tutorial in Materials Science NA
One-half credit course for the year designed for students interested in the chemistry research experience in the synthesis and structural characterization of organically templated microporous materials. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.
361 Research Tutorial in Physical Chemistry NA
Directed research in physical chemistry, condensed phase chemical physics, and biophysical chemistry, with emphasis on spectroscopic studies of site-specific environmental and conformational dynamics in peptides and proteins. Prerequisite: Consent.
362 Research Tutorial in Theoretical Chemistry NA
Directed research in computational and theoretical physical chemistry, with emphasis on development and application of methods for prediction of optical, electronic, and mechanical properties of organic and inorganic semiconductor nanostructures. Prerequisite: Consent.
364 Research Tutorial in Bioorganic Chemistry NA
Directed research in bioorganic chemistry. Topics include protein structure-function relationship studies and the design and synthesis of a broad range of peptides, proteins and biologically inspired novel materials. Prerequisite: Consent
365 Research Tutorial in Bioinorganic Chemistry NA
Topics include spectroscopic and kinetic studies of metalloproteins and inorganic coordination compounds. Prerequisite: Consent.
368 Research Tutorial in Environmental Chemistry NA
Directed research in environmental chemistry, centered in the field of biogeochemistry, a multidisciplinary approach focused at understanding the chemical composition and processes of Earth's biosphere. Prerequisite: Consent.
369 Research Tutorial in Materials Science NA
Topics include synthesis and structural characterization of organically templated microporous materials. Prerequisite: Consent.
SENIOR RESEARCH, INDEPENDENT STUDY AND SENIOR DEPARTMENTAL STUDIES
493 Interdisciplinary Examinations of Biologically Significant Research NA (Cross-listed in Biology and Physics and Psychology)
Prerequisite: Consent of Instructor.
SELECTED COURSES OFFERED AT BRYN MAWR COLLEGE
The following courses may be used to satisfy the advanced course requirement of the chemistry major.
242 Biological Chemistry
315 Medicinal Chemistry
332 Advanced Inorganic Chemistry
345 Advanced Biological Chemistry