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Haverford College

2012-13 Course Catalog

Natural Sciences: Chemistry, 2012-13

DescriptionFacultyMajor RequirementsMinor RequirementsRequirements for HonorsCoursesDepartment Homepage

Description

The program in chemistry is designed to meet the needs of students who are pursuing chemistry either for a variety of pre-professional reasons or to increase their knowledge of the natural sciences. Therefore, Haverford has a chemistry major program that provides preparation for careers in science, medicine, law, business and K—12 education, as well as a number of other professions.

The major program recognizes that chemistry as a discipline is a core science but is also intertwined with a number of other fields, including physics, biology and mathematics/computer science. In fact, some of the most exciting areas in science today are found in the interdisciplinary fields of chemical physics, chemical biology, theoretical/computational chemistry, environmental studies and materials science. The chemistry major allows the student flexibility in designing a program that he/she can direct toward such interdisciplinary areas or to one of the more traditional areas of organic, physical or inorganic chemistry. In addition, the chemistry department is one of the sponsor departments of the concentrations in scientific computing and biochemistry and biophysics and contributes courses to the minor in environmental studies.

Students have three possible entry points into the program. The particular entry point or placement depends on the level of preparation of the individual student and is determined by the combination of results from a placement questionnaire, secondary-school records, scores from standardized and advanced placement tests, and individual consultation. All three starting points can result in the completion of the chemistry major program. Students with no to limited previous chemistry experience enter the first-year chemistry sequence with an intensive version of CHEM 111. This course is followed by CHEM 112, offered during the second semester. CHEM 112 also offers an intensive section by placement depending on student performance. The second entry point is for those students with typical high school chemistry preparation. They take two semesters of introductory course work (CHEM 111 and CHEM 112). The third entry point is for students with an excellent high school chemistry background, who take Chemistry 115, which includes the CHEM 111 lecture and a more investigative, independent lab program, and CHEM 112. All students can continue the following year with CHEM 222 in organic biological chemistry, and CHEM 225, which focuses on organic synthesis.

All seniors are required to participate in a research program for advanced course credit, and first- to third-year students with strong interests in chemistry can get involved with research through 260-level courses. This research experience nurtures talents and abilities, encourages independent problem solving and builds on concepts and principles discussed in prior formal class work. It also can help the student define choices for careers after graduation. We also encourage summer research experience, which provides a background of focused work that can greatly enrich the senior thesis research experience. In recent years, 20 to 30 students per summer have received stipends to participate in research in the chemistry department.

Chemistry majors wishing to study abroad during the junior year should confer with the faculty advisor and should plan to take at least one chemistry course per semester at the foreign institution. The chemistry department has currently approved international study abroad programs at Oxford University (England), University College London (England), University of Melbourne (Australia) and University of Aberdeen (Scotland). Chemistry majors have also recently studied at University of Stockholm (Sweden), Queen's University (Northern Ireland), National University of Ireland (Ireland), University of the West Indies (Barbados) and University of Cape Town (South Africa). Chemistry majors have also satisfied major requirements using courses from domestic programs such as the Semester in Environmental Science at the Marine Biological Laboratory in Woods Hole, Massachusetts.

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Faculty

John Farnum Professor of Chemistry, emeritus Colin MacKay
Professor Terry Newirth, emeritus
Professor Claude E. Wintner, emeritus
Professor Karin Åkerfeldt, chair
Professor Robert Scarrow
Associate Professor Frances Rose Blase
Associate Professor Alexander Norquist
Assistant Professor Casey Londergan
Assistant Professor Joshua Schrier
Assistant Professor Helen White (on leave 2012-2013)
Visiting Professor Charles Lerman
Visiting Professor Mark Schofield
General Chemistry Laboratory Instructor Kelly Matz
Organic Chemistry Laboratory Instructor Michael J. Kukla
Organic Biology Chemistry Laboratory Instructor Mark Stein

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Major Requirements

Each student confers with the major advisor to plan a program that takes into account specific interests and career aims. An American Chemical Society (ACS) certified major requires additional coursework and is recommended for students interested in pursuing graduate study in science and engineering, or who wish to directly enter the job market in a chemistry related field after graduation.

Chemistry Major

The core required courses are: CHEM 111 or 115, 112, 222, 225, 301, 302, 304 or 305, at least one semester of CHEM 380 or 36x (research tutorials), one semester of inorganic chemistry (CHEM 320, half–semester) and one half–semester course from the following: 351, 353 and 354 and 391 (senior seminar). Chemistry majors must also complete one semester of additional advanced chemistry courses numbered 304–358; one semester of mathematics courses numbered MATH 114 (calculus II) or higher; and either introductory physics (PHYS 101/102 or 105/106) or both semesters of BIOL 200.

Chemistry Major with Biochemistry Concentration

Students with a biochemistry concentration can substitute either semester of BIOL 300 for CHEM 302. (CHEM 301 [Superlab I] is required for all chemistry majors and cannot be replaced.) Concentrators also must take one semester of an advanced biology course (see the Biochemistry and Biophysics section of this catalog for a current list of advanced Biology courses), and two half semester advanced chemistry courses with a biological emphasis. These include CHEM 351 (half–semester, bioinorganic), CHEM 352 (half–semester, biophysical) or CHEM 357 (half–semester, bioorganic). BIOL 200a, 200b, PHYS 101/102 or 105/106 are required for biochemistry concentrators.

Chemistry Major with Scientific Computing Concentration

See the Computer Science page for details on this concentration. In the chemistry department, courses that can contribute to this concentration are CHEM 304, CHEM 305, and CHEM 362; we also encourage students to enroll in CHEM B322 when offered. The department coordinator for this concentration is Joshua Schrier.

ACS-Certified Chemistry Major

In order to receive ACS-certification, students must satisfy all of the major requirements (with or without a biochemistry concentration) above and, as an additional course, must complete the second semester of physical chemistry (CHEM 304 or 305). The following requirements also apply for ACS-certification and may be met with the same courses used to meet major requirements: PHYS 101/102 or 105/106 and at least one semester of biochemistry. Students may satisfy this last requirement by BIOL 200 (second semester), by Bryn Mawr CHEM 242 or two half-semester courses of CHEM 351, 352 or 357.

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Minor Requirements

The required courses are: CHEM 111 or 115,112, 222, 225, 304 or 305, and one semester of advanced chemistry chosen from courses numbered 301–369. Students must take at least three of the courses for the chemistry minor at Haverford. The senior seminar (CHEM 391) is not required, but attendance at seminars, including the Philips Visitor Series in Chemistry, is strongly recommended.

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Requirements for Honors

All students who participate in senior research are considered for departmental honors. Successful honors candidates are expected to do superior work in major courses and to complete a research problem at a level that is superior both in quality and quantity of effort to that expected in normal course work.

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Courses

A CORE PROGRAM OF COURSES IN MOLECULAR, CELL AND DEVELOPMENTAL BIOLOGY WITH PREREQUISITES

300 Laboratory in Biochemistry and Molecular Biology NA (Cross-listed in Biology)

<Prerequisite: BIOL 330D or the instructor’s consent.

SENIOR RESEARCH, INDEPENDENT STUDY AND SENIOR DEPARTMENTAL STUDIES

493 Interdisciplinary Examinations of Biologically Significant Research NA (Cross-listed in Biology and Physics and Psychology)

P.Meneely
Prerequisite: the instructor’s consent.

111 Chemical Structure and Bonding NA

A. Norquist/K. Matz
Exploring structure and bonding in molecules starting from the nuclear and electronic structure of atoms, this course introduces the theories of chemical bonding that rationalize and predict the structures and bulk properties of molecules and materials. It also introduces modern instrumental and computational methods used to study chemical structure and bonding. Students attend a three-hour lab, which meets every Wednesday from 1:00-4:00. Prerequisite: A high school chemistry course and departmental placement. Typically offered every fall.

112 Chemical Dynamics NA/QU

C. Londergan/K. Matz
This is an introduction to chemical thermodynamics, equilibrium, electrochemistry and kinetics. We use microscopic properties to develop basic chemical concepts of energy, enthalpy, entropy and the Gibbs Energy, and their applications to thermochemistry, equilibria and electrochemistry. We also discuss chemical kinetics, reaction mechanisms, and applications to chemical problems. Prerequisite: Placement by the chemistry department. Typically offered every spring.

115 Chemical Structure and Bonding with Inquiry Lab NA

C.Londergan
In addition to the lecture component of Chemistry 111 (sections 1 or 2 only), students become acquainted with modern methods of chemical structure analysis as they discover the identity of unknown chemical compounds via self-proposed experiments. The class requires three lectures, one lab period, and one laboratory planning meeting each week. Prerequisite: Placement by the department. Typically offered every Fall.

151 Case Studies in Chemistry NA

C.Lerman
This course is intended for non-science majors. It explore aspects of the structure and properties of atoms and molecules, and how they account for observable phenomena within the topics of light, radiation and color. We draw illustrations from various fields of science and everyday life. Concepts are developed both qualitatively and quantitatively. The class is not open to students with prior college-level chemistry. Does not count toward the major. Typically offered every spring.

152 Chemistry: Its Application to the Everyday World NA

Staff
Made up of three lectures, this course for non-science majors discusses the many ways science and chemistry affect our lives. We discuss fundamental principles of chemical bonding, structure and reactivity. Concepts are developed both qualitatively and quantitatively to link phenomena that can be observed to basic properties of matter. Does not count toward the major. Offered occasionally.

222 Organic Biological Chemistry NA (Cross-listed in Biochemistry)

K. Akerfeldt/M. Stein
This is a survey of organic chemistry reactions in an aqueous environment, highlighting transformations important for understanding the properties and reactivity of biomolecules in the cell, with emphasis on functional groups, acids and bases, chirality, energetics, reaction mechanisms, enzyme inhibitors and drug design. Prerequisite: CHEM 111 or 115 and CHEM 112, or the instructor’s consent. Typically offered every fall.

225 Organic Reactions and Synthesis NA (Cross-listed in Biochemistry)

F.Blase/M. Kukla
This course explores organic reactions in mechanistic detail, and highlights their use in the syntheses of complex organic molecules. It concentrates on functional group transformations and then delves into organometallic and enantioselective reactions for use in complex syntheses. Prerequisite: CHEM 222 or the instructor’s consent Typically offered every spring.

261 Research Tutorial in Physical Chemistry NA

C. Londergan
This one-half credit course for the year is designed for students interested in the chemistry research experience in physical chemistry, condensed phase chemical physics and biophysical chemistry, with emphasis on spectroscopic studies of peptides and proteins. Not open to seniors. Prerequisite: The instructor’s consent. Does not count toward the major.

301 Lab in Chemical Structure and Reactivity NA

M. Schofield
Comprised of two lectures and two laboratory periods, this is an introduction to the methods of research in chemistry. It integrates inorganic, organic, physical chemistry, computational chemistry and biochemical concepts in a broad laboratory study of structure and its relationship to chemical reactivity. We use physical methods in studies of organic, inorganic and biochemical reactions. In particular the class stresses chemical synthesis and the modern methods of computation and instrumental analytical chemistry. Prerequisite: CHEM 221B, (co-requisite: 304A). Typically offered every Fall.

302 Lab in Chemical Structure and Reactivity NA

A. Norquist/R. Scarrow
Comprised of two lectures and two laboratory periods, this is an introduction to the methods of research in chemistry. It integrates inorganic, organic, physical chemistry and biochemical concepts in a broad laboratory study of structure and its relationship to chemical reactivity. We use physical methods in studies of organic, inorganic, and biochemical reactions. In particular the class stresses chemical synthesis and the modern methods of instrumental analytical chemistry. Students use instruments such as lasers, the 500 MHz NMR spectrometer and the mass spectrometer (combined with either gas or liquid chromatography), with faculty supervision. Prerequisite: CHEM 221 or 225 and CHEM 304. Typically offered every Spring.

304 Statistical Thermodynamics and Kinetics NA/QU

C. Londergan
Comprised of three lectures, this course covers a quantitative approach to the description and prediction of behavior in chemical systems. Topics include: introductory quantum mechanics and energy in molecules, statistical mechanics and energy partitioning, thermodynamics of molecules and larger systems, physical and chemical equilibrium, and chemical kinetics. Systems of interest range from single molecules to complicated condensed-phase macromolecular assemblies; we will discuss specific experimental examples of single-molecule observation, phase changes in lipids and liquid crystals, and observations of protein folding in the context of the course material. Prerequisite: one semester of MATH 114 or 115, MATH 121 or 216 is highly recommended. Typically offered every Fall.

305 Quantum Chemistry NA

J.Schrier
quantum theory of atoms and molecules as applied to problems in molecular structure, computational chemistry, and basic spectroscopic techniques. There is an emphasis on computer-based solutions and visualization. Prerequisite: MATH 121 or 216. Typically offered every Spring.

320 Concepts of Inorganic Chemistry NA

A.Norquist
This course, which requires three lectures for one-half semester (one-half course credit), is an introduction to the structure and reactivity of inorganic molecules and materials. Topics include: theories of chemical bonding, symmetries of molecules and solid state materials, acid-base, oxidation-reduction reactions, and structures and nomenclature of coordination complexes. Prerequisite: CHEM 221 or 225 or the instructor’s consent. Typically offered every Spring.

340 Molecular Spectroscopy NA

C.Londergan
Requiring two lectures for one-half semester (one-half course credit), this course explores a quantum mechanical description of current techniques in the spectroscopy of molecules. Prerequisite: CHEM 305 or PHYS 214 or the instructor’s consent. Offered occasionally.

351 Bioinorganic Chemistry NA

R.Scarrow
This course requires three lectures for one-half semester (one-half course credit). Biological cells require metals such as zinc, iron, copper, manganese, and molybdenum. Topics of discussion include: metal-binding abilities of various functional groups within proteins and nucleic acids, metal-based reactivity involved in reaction mechanisms of specific metalloenzymes, and medically relevant topics such as bioaccumulation and storage of metal ions, the toxicity of heavy metals, and use of metal-containing drugs in treating disease. Prerequisite: CHEM 320 or the instructor’s consent. Typically offered every Spring.

352 Topics in Biophysical Chemistry NA

Staff
Prerequisite: CHEM 304. Offered occasionally.

353 Topics in Materials Science NA

J.Schrier
Requiring three lectures for one-half semester (one-half course credit), this course focuses on the structure-property relationship central to the study of materials with specific functions. Structural studies include bonding, order/disorder and non-stoichiometry in crystalline and non-crystalline solids. We discuss optical, magnetic and electronic properties in context of non-linear optical materials, ferroelectric and magnetoresistant materials, and superconductors and semiconductors. Prerequisite: CHEM 304 or PHYS 214 & CHEM 101b or 105b Typically offered every fall.

354 Solid State Chemistry NA

A.Norquist
Requiring three lectures for one-half semester (one-half course credit), this is an examination of the reactivity of solids. It emphasizes synthetic techniques and structural analyses. Prerequisite: CHEM 304 or the instructor’s consent. Typically offered every Spring.

355 Topics in Advanced Organic Chemistry NA

M.Schofield
Requiring three lectures for one-half semester (one-half course credit), this course has variable content, depending on the interests of students and faculty. Topics are selected in consultation with students electing the course. Previous topics have included: modern synthetic methods, asymmetric synthesis, natural product chemistry, biosynthesis, chemistry of coenzymes, combinatorial approaches to synthesis, free radical chemistry and organometallic chemistry. Topics selected differ from those selected for 357 in the previous year. Prerequisite: CHEM 221 or 225 or the instructor’s consent. Offered occasionally.

357 Topics in Bioorganic Chemistry NA

K. Akerfeldt/M. Schofield
Requiring three lectures, this course has content that varies, depending on faculty and student interests. The course focuses on organic chemistry as applied to biological systems and related topics. Prerequisite: CHEM 221 or 225 or the instructor’s consent.

358 Environmental Chemistry NA

R.Scarrow
Requiring three lectures for one-half semester (one-half course credit), this course examines chemical processes that occur in natural waters, soils and the atmosphere. Specific topics are chosen with input from enrolled students, who are expected to share in discussion leadership. Students may repeat CHEM 358 once for credit as long as the topics differ. For fall 2012, the theme of the course is "Metals in the Environment." Prerequisite: CHEM 304 (or similar) or the instructor’s consent. Typically offered in alternate years.

380 Independent Research in Chemistry NA

Staff
This course is for chemistry majors who want to pursue a library research experience. Students work closely with a faculty member on a topic in the current chemical literature to prepare a thesis paper. Prerequisite: CHEM 225 and 304.

391 Departmental Seminar NA

R.Scarrow
Requiring one meeting per week throughout the year (one-half course credit), this seminar involves presentation and discussion of current research topics in the various areas of chemistry by faculty, students and outside speakers.

480 Independent Study NA

Faculty

364 Research Tutorial in Bioorganic Chemistry NA

K.Åkerfeldt
This tutorial invovles directed research in bioorganic chemistry. Topics include protein structure-function relationship studies and the design and synthesis of a broad range of peptides, proteins and biologically inspired novel materials. Prerequisite: The instructor’s consent.

RESEARCH TUTORIALS

Students may register for a research tutorial in an area of active faculty research. In these tutorials the student attempts to define and solve a research problem under the close supervision of a faculty member.

262 Research Tutorial in Theoretical Chemistry NA

J.Schrier
This one-half credit course for the year is designed for students interested in the chemistry research experience in theoretical physical chemistry, with emphasis on methods for prediction of optical, electronic and mechanical properties of organic and inorganic semiconductor nanostructures. Not open to seniors. Prerequisite: The instructor’s consent. Does not count toward the major.

263 Research Tutorial in Organic Chemistry NA

F.Blase
This one-half credit course for the year is designed for students interested in the chemistry research experience in synthetic organic chemistry and physical-organic chemistry. Topics include total synthesis of biologically significant molecules, new methods of enantioselective synthesis and the study of organic reaction mechanisms. Not open to seniors. Prerequisite: The instructor’s consent. Does not count toward the major.

264 Research Tutorial in Bioorganic Chemistry NA

K.Åkerfeldt
This one-half credit course for the year is designed for students interested in the chemistry research experience in protein structure-function relationship studies and the design and synthesis of a broad range of peptides, proteins and biologically inspired novel materials. Not open to seniors. Prerequisite: The instructor’s consent. Does not count toward the major.

265 Research Tutorial in Bioinorganic Chemistry NA

R.Scarrow
This one-half credit course for the year is designed for students interested in the chemistry research experience in spectroscopic and kinetic studies of metalloproteins and inorganic coordination compounds. Not open to seniors. Prerequisite: The instructor’s consent. Does not count toward the major.

268 Research Tutorial in Environmental Chemistry NA

H.White
This one-half credit course for the year designed for students interested in the chemistry research experience in the field of biogeochemistry, a multidisciplinary approach focused at understanding the chemical composition and processes of Earth's biosphere. Not open to seniors. Prerequisite: The instructor’s consent. Does not count toward the major.

269 Research Tutorial in Materials Science NA

A.Norquist
This one-half credit course for the year is designed for students interested in the chemistry research experience in the synthesis and structural characterization of organically templated microporous materials. Not open to seniors. Prerequisite: The Instructor’s consent. Does not count toward the major.

361 Research Tutorial in Physical Chemistry NA

C.Londergan
This tutorial involves directed research in physical chemistry, condensed phase chemical physics and biophysical chemistry, with emphasis on spectroscopic studies of site-specific environmental and conformational dynamics in peptides and proteins. Prerequisite: The instructor’s consent.

362 Research Tutorial in Theoretical Chemistry NA

J.Schrier
This tutorial involves directed research in computational and theoretical physical chemistry, with emphasis on development and application of methods for prediction of optical, electronic and mechanical properties of organic and inorganic semiconductor nanostructures. Prerequisite: The instructor’s consent.

363 Research Tutorial in Organic Chemistry NA

F.Blase
This tutorial involves directed research in synthetic organic chemistry and physical-organic chemistry. Topics include total synthesis of biologically significant molecules, new methods of enantioselective synthesis and the study of organic reaction mechanisms. Prerequisite: The instructor’s consent.

365 Research Tutorial in Bioinorganic Chemistry NA

R. Scarrow/M. Schofield
This tutorial cover topics including spectroscopic and kinetic studies of metalloproteins and inorganic coordination compounds. Prerequisite: The instructor’s consent.

368 Research Tutorial in Environmental Chemistry NA

H.White
This tutorial involves directed research in environmental chemistry, centered in the field of biogeochemistry, a multidisciplinary approach to understanding the chemical composition and processes of Earth's biosphere. Prerequisite: The instructor’s consent.

369 Research Tutorial in Materials Science NA

A.Norquist
Topics of this tutorialinclude synthesis and structural characterization of organically templated microporous materials. Prerequisite: The instructor’s consent.

SELECTED COURSES OFFERED AT BRYN MAWR COLLEGE

The following courses may be used to satisfy the advanced course requirement of the chemistry major.
242 Biological Chemistry
332 Advanced Inorganic Chemistry
334 Organometallic Chemistry
345 Advanced Biological Chemistry

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