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Haverford College

2011-12 Course Catalog

Natural Sciences: Chemistry, 2011-12

DescriptionFacultyMajor RequirementsMinor RequirementsRequirements for HonorsCoursesDepartment Homepage

Description

The program in chemistry is designed to meet the needs of students who are pursuing chemistry either for a variety of pre-professional reasons or to increase their knowledge of the natural sciences. Therefore, Haverford has a chemistry major program that provides preparation for careers in science, medicine, law, business, K-12 education as well as a number of other professions.

The major program recognizes that chemistry as a discipline is a core science, but is also intertwined in a number of other fields, including physics, biology and math/computer science. In fact, some of the most exciting areas in science today are found in the interdisciplinary fields of chemical physics, chemical biology, theoretical/computational chemistry, environmental studies and materials science. The chemistry major allows the student flexibility in designing a program that can be directed toward such interdisciplinary areas or to one of the more traditional areas of organic, physical or inorganic chemistry. In addition, the chemistry department is one of the sponsor departments of the concentrations in scientific computing and biochemistry and biophysics and contributes courses to the minor in Environmental Studies.

Students have three possible entry points into the program. The particular entry point or placement depends on the level of preparation of the individual student and is determined by the combination of results from a placement questionnaire, secondary school records, scores from standardized and advanced placement tests, and individual consultation. All three starting points can result in the completion of the chemistry major program. For the first entry point, no previous chemistry experience is required and students enter the first year of the general chemistry sequence with a Foundations course (Chem 110) followed by the regular introductory courses (Chem 111 and Chem 112). The second entry point is for those students with a typical good high school chemistry preparation. They will take two semesters of introductory course work (Chem 111 and 112). The third entry point is for students with an excellent high school chemistry background, who can omit Chem 111 and take only Chem 112 along with a half credit investigative lab course, Chem 115, which introduces spectroscopy. These advanced first-year students have an extra course slot available in their first semester that might be used for a mathematics and/or a physics course. Students will continue the following year with Chem 222, an organic biological chemistry course and Chem 225, an organic synthesis course.

All students as seniors are required to participate in a research program for advanced course credit, and first to third year students with strong interests in Chemistry are able to get involved with research throughout 260 level courses. This research experience nurtures talents and abilities, encourages independent problem solving and builds on concepts and principles discussed in prior formal class work. It also can help the student define choices for careers after graduation. Summer research experience is particularly encouraged. The summer experience provides a background of focused work that can greatly enrich the senior thesis research experience. In recent years, twenty to thirty students per summer have received stipends to participate in research in the chemistry department.

Chemistry majors wishing to study abroad during the junior year should confer with the faculty advisor and should plan to take at least one chemistry course per semester at the foreign institution. The chemistry department has currently approved international study abroad programs at Oxford University (England), University College London (England), University of Melbourne (Australia) and University of Aberdeen (Scotland). Chemistry majors have also recently studied at University of Stockholm (Sweden), Queen's University (Northern Ireland) and National University of Ireland (Ireland). Chemistry majors have also satisfied major requirements using courses from domestic programs such as the Semester in Environmental Science at the Marine Biological Laboratory in Woods Hole, Massachusetts.

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Faculty

John Farnum Professor of Chemistry Colin MacKay, Emeritus
Professor Claude E. Wintner, Emeritus
Professor Karin ÅkerfeldtChairperson
Professor Terry Newirth, (on leave 2011-12)
Professor Robert Scarrow
Associate Professor Frances Rose Blase
Associate Professor Alexander Norquist
Assistant Professor Casey Londergan
Assistant Professor Joshua Schrier(on leave 2011-12)
Assistant Professor Helen White
Visiting Professor Charles Lerman
Visiting Professor Mark Schofield
General Chemistry Laboratory Instructor Kelly Matz
Organic Chemistry Laboratory Instructor Michael J. Kukla

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Major Requirements

Each student confers with the major advisor to plan a program that takes into account specific interests and career aims. The major requirements have been designed to meet the educational needs of students interested in careers in chemistry, biochemistry, engineering, medicine, K-12 education, business, law and other professions. An American Chemical Society (ACS) certified major requires additional coursework and is recommended for students interested in pursuing graduate study in science and engineering, or who wish to directly enter the job market in a chemistry-related field after graduation.

Chemistry Major

The core required courses are: Chemistry 111 or 115, 112, 222, 225, 301, 302, 304 or 305, at least one semester of 380 or 36x (research tutorials), one semester of inorganic chemistry (Chemistry 320, 0.5 semester) and one half semester course from the following: 351, 353 and 354 and 391 (senior seminar). Chemistry majors must also complete one semester of additional advanced chemistry courses numbered 304-358; one semester of mathematics courses numbered 114 (calculus II) or higher; and either introductory physics (Physics 101/102 or 105/106) or both semesters of Biology 200.

Chemistry Major with Biochemistry Concentration

Biochemistry concentrators are allowed to substitute either semester of Biology 300 for Chemistry 302. (Chemistry 301 [Superlab I] is required for all chemistry majors and cannot be replaced.) Concentrators also must take one semester of an advanced biology course (see the Biochemistry and Biophysics section of this catalog for a current list of advanced Biology courses), and two half semester advanced chemistry courses with a biological emphasis. These include Chem 351 (0.5 semester, bioinorganic), Chem 352 (0.5 semester, biophysical) or Chem 357 (0.5 semester, bioorganic). Biology 200a, 200b, Physics 101/102 or 105/106 are required for biochemistry concentrators.

Chemistry Major with Scientific Computing Concentration

See the Computer Science page for details on this concentration. In the chemistry department, courses which can contribute to this concentration are Chem 304, Chem 305, and Chem 362; students are also encouraged to enroll in Chem B322 when offered. The department coordinator for this concentration is Joshua Schrier.

ACS-Certified Chemistry Major

In order to receive ACS-certification, students must satisfy all of the major requirements (with or without a biochemistry concentration) above and as an additional course must complete the second semester of physical chemistry (304 or 305). The following requirements also apply for ACS-certification and may be met with the same courses used to meet major requirements: Physics 101/102 or 105/106 and at least one semester of biochemistry. This last requirement may be satisfied by Biology 200 (second semester), by Bryn Mawr Chemistry 242, or by two half-semester courses of Chemistry 351, 352 or 357.

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Minor Requirements

The required courses are: Chemistry 111 or 115,112, 222, 225, 304 or 305, and one semester of advanced chemistry chosen from courses numbered between 301 and 369. At least three of the courses taken for the chemistry minor must be taken at Haverford College. The senior seminar (Chemistry 391) is not required, but attendance at seminars, including the Philips Visitor Series in Chemistry, is strongly recommended.

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Requirements for Honors

All students who participate in senior research will be considered for departmental honors. Successful honors candidates will be expected to do superior work in major courses and to complete a research problem at a level superior both in quality and quantity of effort to that expected in normal course work.

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Courses

110 Fundamentals of Chemistry NA/QU

F.Blase
Topics include dimensional analysis, atomic structure, nuclear chemistry, Lewis structures, behavior of gases, stoichiometry in solid, liquid and gas phase reactions, thermochemistry and intermolecular forces. This course does not count toward the chemistry major, but will serve as a foundation to Chemistry 111 (Structure and Bonding) and Chemistry 112 (Dynamics), which are required for the major. Prerequisite: No high school chemistry or placement by department. Does not count toward the major. Typically offered every Fall.

111 Chemical Structure and Bonding NA

R.Scarrow/K. Matz
Structure and bonding in molecules starting from nuclear and electronic structure of atoms. This course introduces the theories of chemical bonding that rationalize and predict the structures and bulk properties of molecules and materials. It also introduces modern instrumental and computational methods used to study chemical structure and bonding. Prerequisite: High school chemistry course and placement by the Department. Three-hour lab meets every other week. Typically offered every Semester.

112 Chemical Dynamics NA/QU

H.White/K.Matz
An introduction to chemical thermodynamics, equilibrium, electrochemistry and kinetics. Microscopic properties are used to develop basic chemical concepts of energy, enthalpy, entropy and the Gibbs Energy, and their applications to thermochemistry, equilibria and electrochemistry. Chemical kinetics, reaction mechanisms and applications to chemical problems are also discussed. Three-hour lab, meets every other week. Prerequisite: High school chemistry course and Placement by the Department. Typically offered every Semester.

115 Chemical Structure Inquiry Lab NA

C.Londergan
Students will become acquainted with modern methods of chemical structure analysis as they discover the identity of unknown chemical compounds via self-proposed experiments. Prerequisite: Placement by the Department. Typically offered every Fall.

151 Case Studies in Chemistry NA

C.Lerman
This course is intended for non-science majors. It will explore aspects of the structure and properties of atoms and molecules, and how they account for observable phenomena within the topics of light, radiation and color. Illustrations will be drawn from various fields of science and everyday life. Concepts will be developed both qualitatively and quantitatively. Not open to students with prior college-level chemistry. Does not count toward the major.

222 Organic Biological Chemistry NA (Cross-listed in Biochemistry)

K.Akerfeldt, Staff
Survey of organic chemistry reactions in an aqueous environment, highlighting transformations important for understanding the properties and reactivity of biomolecules in the cell, with emphasis on functional groups, acids and bases, chirality, energetics, reaction mechanisms, enzyme inhibitors and drug design. Prerequisite: Chemistry 111 or 115 and Chemistry 112, or consent of instructor. Typically offered every Semester

225 Organic Reactions and Synthesis NA (Cross-listed in Biochemistry)

F.Blase/M. Kukla
This course will explore organic reactions in mechanistic detail, and highlight their use in the syntheses of complex organic molecules. It will concentrate on functional group transformations and then delve into organometallic and enantioselective reactions for use in complex syntheses. Prerequisite: Chemistry 111 (or Chemistry 115), Chemistry 112 and Chemistry 222 (Organic Biological Chemistry) or consent of instructor. Typically offered every Spring.

300 Laboratory in Biochemistry and Molecular Biology NA (Cross-listed in Biology)

K.Johnson/A.Morris/Staff
Prerequisite: Biology 200 or consent.

301 Lab in Chemical Structure and Reactivity NA

F. Blase/A. Norquist/M. Schofield
Two lectures and two laboratory periods. An introduction to the methods of research in chemistry. Inorganic, organic, physical chemistry, computational chemistry and biochemical concepts are integrated in a broad laboratory study of structure and its relationship to chemical reactivity. Physical methods are used in studies of organic, inorganic and biochemical reactions. Chemical synthesis and the modern methods of computation and instrumental analytical chemistry are particularly stressed. Prerequisite: Chemistry 221B (last taught Spring 2011). (Co-requisite: 304A.) Typically offered every Fall.

302 Lab in Chemical Structure and Reactivity NA

H.White/C.Londergan
Two lectures and two laboratory periods. An introduction to the methods of research in chemistry. Inorganic, organic, physical chemistry and biochemical concepts are integrated in a broad laboratory study of structure and its relationship to chemical reactivity. Physical methods are used in studies of organic, inorganic and biochemical reactions. Chemical synthesis and the modern methods of instrumental analytical chemistry are particularly stressed. Instruments such as lasers, the 300 MHz NMR spectrometer and the mass spectrometer combined with either gas or liquid chromatography are used by students with faculty supervision. Prerequisite: Chemistry 221B (last taught Spring 2011) and 304A. Typically offered every Spring.

304 Statistical Thermodynamics and Kinetics NA/QU

C. Londergan
Three lectures. A quantitative approach to the description and prediction of behavior in chemical systems. Topics to be covered include: introductory quantum mechanics and energy in molecules, statistical mechanics and energy partitioning, thermodynamics of molecules and larger systems, physical and chemical equilibrium, and chemical kinetics. Systems of interest range from single molecules to complicated condensed-phase macromolecular assemblies; specific experimental examples of single-molecule observation, phase changes in lipids and liquid crystals, and observations of protein folding will be discussed in the context of the course material. Prerequisite: one semester of Math 114 or 115, Math 121 or 216 is highly recommended. Typically offered every Fall.

305 Quantum Chemistry NA

C.Londergan
Two lectures. The quantum theory of atoms and molecules as applied to problems in molecular structure, computational chemistry and basic spectroscopic techniques. Emphasis on computer-based solutions and visualization. Prerequisite: Math 121 or 216. Typically offered every Spring.

320 Concepts of Inorganic Chemistry NA

R.Scarrow
Three lectures for one-half semester (one-half course credit). An introduction to structure and reactivity of inorganic molecules and materials. Topics include: theories of chemical bonding, symmetries of molecules and solid state materials, acid-base, oxidation-reduction reactions, and structures and nomenclature of coordination complexes. Prerequisite: Chemistry 304a. Typically offered every Spring.

340 Molecular Spectroscopy NA

C.Londergan
Two lectures for one-half semester (one-half course credit). Quantum mechanical description of current techniques in the spectroscopy of molecules. Prerequisite: Chemistry 305 or Physics 214 or consent of instructor. Offered occasionally.

351 Bioinorganic Chemistry NA

R.Scarrow
Three lectures for one-half semester (one-half course credit). Biological cells require metals such as zinc, iron, copper, manganese and molybdenum; metal-binding abilities of various functional groups within proteins and nucleic acids, metal-based reactivity involved in reaction mechanisms of specific metalloenzymes, and medically-relevant topics such as bioaccumulation and storage of metal ions, the toxicity of heavy metals and use of metal-containing drugs in treating disease will be discussed. Prerequisite: Chemistry 221 (last taught Spring 2011) or 304, or consent of instructor. Students should have completed 320g or a Biology course involving protein structure. Typically offered every Spring.

352 Topics in Biophysical Chemistry NA

Staff
Prerequisite: Chemistry 304A. Offered occasionally.

353 Topics in Materials Science NA

A.Norquist
Three lectures for one-half semester (one-half course credit) This course will focus on the structure-property relationship central to the study of materials with specific functions. Structural studies will include bonding, order/disorder and non-stoichiometry in crystalline and non-crystalline solids. Optical, magnetic and electronic properties will be discussed in the context of non-linear optical materials, ferroelectric and magnetoresistant materials, as well as superconductors and semiconductors. Prerequisite: Chemistry 304 or Physics 214 and Chemistry 101b or Chemistry 105b (both last taught 2009-2010). Typically offered every Fall.

354 Solid State Chemistry NA

A.Norquist
Three lectures for one-half semester (one-half course credit) An examination of the reactivity of solids. Synthetic techniques and structural analyses will be emphasized. Prerequisite: Chemistry 304 or Physics 214 and Chemistry 101 or 105 (both last taught 2009-2010). Typically offered every Spring.

355 Topics in Advanced Organic Chemistry NA

M.Schofield
Three lectures for one-half semester (one-half course credit). Variable content, depending on the interests of students and faculty. Topics are selected in consultation with students electing the course. Previous topics have been modern synthetic methods, asymmetric synthesis, natural product chemistry, biosynthesis, chemistry of coenzymes, combinatorial approaches to synthesis, free radical chemistry and organometallic chemistry. Topics selected differ from those selected for 357 in the previous year. Prerequisite: Chemistry 221 (last taught Spring 2011). Offered occasionally.

357 Topics in Bioorganic Chemistry NA

M.Schofield
Prerequisite: Chemistry 221b (last taught Spring 2011). Typically offered every Semester.

358 Environmental Chemistry NA

H.White
Three lectures for one-half semester (one-half course credit). This course will examine chemical processes that occur in natural waters, soils and the atmosphere. Specific topics will be chosen with input from enrolled students, who will be expected to share in discussion leadership. Prerequisite: Chemistry 304a or equivalent, or permission of instructor. Typically offered in alternate years.

380 Independent Research in Chemistry NA

R.Scarrow
This course is designed for chemistry majors who want to pursue a library research experience. Students will work closely with a faculty member on a topic in the current chemical literature to prepare a thesis paper. Prerequisite: Chemistry 221(last taught Spring 2011) and Chemistry 304.

391 Departmental Seminar NA

K. Åkerfeldt
One meeting per week throughout the year (one-half course credit). Presentation and discussion of current research topics in the various areas of chemistry by faculty, students and outside speakers.

480 Independent Study NA

Staff

493 Interdisciplinary Examinations of Biologically Significant Research NA (Cross-listed in Biology and Physics and Psychology)

P.Meneely
Prerequisite: Consent.

RESEARCH TUTORIALS

Students may register for a research tutorial in an area of active faculty research. In these tutorials the student attempts to define and solve a research problem under the close supervision of a faculty member.

261 Research Tutorial in Physical Chemistry NA

C.Londergan
One-half credit course for the year designed for students interested in the chemistry research experience in physical chemistry, condensed phase chemical physics and biophysical chemistry, with emphasis on spectroscopic studies of peptides and proteins. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.

262 Research Tutorial in Theoretical Chemistry NA

J.Schrier
One-half credit course for the year designed for students interested in the chemistry research experience in theoretical physical chemistry, with emphasis on methods for prediction of optical, electronic and mechanical properties of organic and inorganic semiconductor nanostructures. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.

263 Research Tutorial in Organic Chemistry NA

F.Blase
One-half credit course for the year designed for students interested in the chemistry research experience in synthetic organic chemistry and physical-organic chemistry. Topics include total synthesis of biologically significant molecules, new methods of enantioselective synthesis and the study of organic reaction mechanisms. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.

264 Research Tutorial in Bioorganic Chemistry NA

K.Åkerfeldt
One-half credit course for the year designed for students interested in the chemistry research experience in protein structure-function relationship studies and the design and synthesis of a broad range of peptides, proteins and biologically inspired novel materials. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.

265 Research Tutorial in Bioinorganic Chemistry NA

R.Scarrow
One-half credit course for the year designed for students interested in the chemistry research experience in spectroscopic and kinetic studies of metalloproteins and inorganic coordination compounds. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.

268 Research Tutorial in Environmental Chemistry NA

H.White
One-half credit course for the year designed for students interested in the chemistry research experience in the field of biogeochemistry, a multidisciplinary approach focused at understanding the chemical composition and processes of Earth's biosphere. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.

269 Research Tutorial in Materials Science NA

A.Norquist
One-half credit course for the year designed for students interested in the chemistry research experience in the synthesis and structural characterization of organically templated microporous materials. (Not open to seniors.) Prerequisite: Consent. Does not count toward the major.

361 Research Tutorial in Physical Chemistry NA

C.Londergan
Directed research in physical chemistry, condensed phase chemical physics, and biophysical chemistry, with emphasis on spectroscopic studies of site-specific environmental and conformational dynamics in peptides and proteins. Prerequisite: Consent.

362 Research Tutorial in Theoretical Chemistry NA

J.Schrier
Directed research in computational and theoretical physical chemistry, with emphasis on development and application of methods for prediction of optical, electronic and mechanical properties of organic and inorganic semiconductor nanostructures. Prerequisite: Consent.

363 Research Tutorial in Organic Chemistry NA

F.Blase
Directed research in synthetic organic chemistry and physical-organic chemistry. Topics include total synthesis of biologically significant molecules, new methods of enantioselective synthesis and the study of organic reaction mechanisms. Prerequisite: Consent.

364 Research Tutorial in Bioorganic Chemistry NA

K.Åkerfeldt
Directed research in bioorganic chemistry. Topics include protein structure-function relationship studies and the design and synthesis of a broad range of peptides, proteins and biologically inspired novel materials. Prerequisite: Consent.

365 Research Tutorial in Bioinorganic Chemistry NA

R.Scarrow
Topics include spectroscopic and kinetic studies of metalloproteins and inorganic coordination compounds. Prerequisite: Consent.

368 Research Tutorial in Environmental Chemistry NA

H.White
Directed research in environmental chemistry, centered in the field of biogeochemistry, a multidisciplinary approach focused at understanding the chemical composition and processes of Earth's biosphere. Prerequisite: Consent.

369 Research Tutorial in Materials Science NA

A.Norquist
Topics include synthesis and structural characterization of organically templated microporous materials. Prerequisite: Consent.

SELECTED COURSES OFFERED AT BRYN MAWR COLLEGE

The following courses may be used to satisfy the advanced course requirement of the chemistry major.
242 Biological Chemistry
332 Advanced Inorganic Chemistry
334 Organometallic Chemistry
345 Advanced Biological Chemistry

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