Math Colloquium @ Bryn Mawr: "Evolutionary Dynamics of Targeted Cancer Therapy"Math Colloquium @ Bryn Mawr: "Evolutionary Dynamics of Targeted Cancer Therapy"http://www.haverford.edu/calendar/details/260035Bryn Mawr, Park 338.2014-02-03T16:00:002014-02-03T17:00:00
February 3, 4:00PM–5:00PM
Bryn Mawr, Park 338.
Ivana Božić (Harvard University). Bryn Mawr, Park 338. Starts at 3:30 due to snow.
Bi-College Math Colloquium
"Evolutionary Dynamics of Targeted Cancer Therapy"
Ivana Božić , Harvard University.
Talk at 3:30 in Park 338.
Tea at 3:15 – Park 355, Math Lounge
Abstract: In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. Using a mathematical model of the evolutionary dynamics of cancer in response to treatment and two clinical data sets, we find that dual therapy can result in long-term disease control in most patients, if there are no single mutations that cause cross-resistance to both drugs. We also find that simultaneous therapy with two drugs is much more effective than sequential therapy. Our results provide realistic expectations for the efficacy of new drug combinations and inform the design of trials for new cancer therapeutics.
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