Strange Bedfellows: The Cytoskeleton and Metabolism in BacteriaStrange Bedfellows: The Cytoskeleton and Metabolism in Bacteriahttp://www.haverford.edu/calendar/details/257092KINSC Sharpless Auditorium2013-11-25T14:30:002013-11-25T16:30:00
November 25,2013 2:30PM–4:30PM
KINSC Sharpless Auditorium
Distinguished Visitor Zemer Gitai, Associate Professor of Molecular Biology and Director of Graduate Studies, Princeton University
Though bacterial cells were long thought to lack the intricate subcellular organization of eukaryotes, recent advances in high-resolution imaging have demonstrated that bacterial cells are in fact highly organized. The members of the bacterial cytoskeleton have emerged as key regulators of this cellular organization, coordinating such essential processes as morphogenesis and division. We previously developed a quantitative high-throughput imaging pipeline that enables the use of imaging-based genetics to study bacterial cell biology. I will describe the application of this pipeline to dissecting the function and regulation of bacterial cytoskeletal proteins, focusing on the identification of the CTP synthase metabolic enzyme as a novel conserved cytoskeleton. I will also discuss how these studies have led to a new appreciation of both cytoskeletal evolution and the importance of protein assembly and localization in regulating metabolic networks. Finally, I will discuss how feedback between metabolism and cytoskeletal assembly can benefit bacteria in their natural environments.
Sponsored by the Department of Biology in conjunction with the Distinguished Visitors Program
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