Bio 353 - Apoptosis: A matter of life and death
Fall, 2001
Haverford College
Jenni Punt


September 4


What is apoptosis and why is it so important?


Historical Reviews:

Kerr JFR, Wyllie AH, and Currie AR. Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer. 1972 26: 239-257.

Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell. 1986 Mar 28;44(6):817-29.


September 6


Week 1

Overview of Apoptosis in 2001


How to critique a paper

Current Reviews (Background reading for the whole course)

Blatt NB, Glick GD. Signaling pathways and effector mechanisms pre-programmed cell death. Bioorg Med Chem. 2001 Jun;9(6):1371-84.

Ranger AM, Malynn BA, Korsmeyer SJ. Mouse models of cell death. Nat Genet. 2001 Jun;28(2):113-8.

Paper to critique (together)

Matikainen et al. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nature Genetics 28: 355 (2001).

September 11, 13
Students select from (7) issues

See schedule

September 18, 20
September 25, 27
October 2, 4
October 9, 11
Apoptosis and Disease
Discussions of the relevance of apoptosis to disease research (see e-reserves for appropriate reviews)
October 23, 25
Mini-grant presentations
Students present their grant proposals to the class for 'review'