Bio
353 - Apoptosis: A matter of life and death
Fall, 2001
Haverford College
Jenni Punt
Syllabus
|
Week
|
Topic
|
Papers/Comments
|
|
September
4
|
What is apoptosis and why is it so important?
|
Historical Reviews: Kerr JFR, Wyllie
AH, and Currie AR. Apoptosis: A basic biological phenomenon with wide
ranging implications in tissue kinetics. Br. J. Cancer. 1972 26:
239-257. Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell. 1986 Mar 28;44(6):817-29.
|
|
September 6
|
Week 1 Overview of Apoptosis in 2001 And.. How to critique a paper |
Current Reviews (Background reading for the whole course) Blatt NB, Glick GD.
Signaling pathways and effector mechanisms pre-programmed cell death.
Bioorg Med Chem. 2001 Jun;9(6):1371-84. Ranger AM, Malynn BA, Korsmeyer SJ. Mouse models of cell death. Nat Genet. 2001 Jun;28(2):113-8. Paper to critique
(together) Matikainen et al.
Aromatic hydrocarbon receptor-driven Bax gene expression is required
for premature ovarian failure caused by biohazardous environmental chemicals.
Nature Genetics 28: 355 (2001). |
|
September
11, 13
|
Students
select from (7) issues
|
|
|
September
18, 20
|
||
|
September
25, 27
|
||
|
October
2, 4
|
||
|
October
9, 11
|
Apoptosis
and Disease
|
Discussions
of the relevance of apoptosis to disease research (see e-reserves
for appropriate reviews)
|
|
October
23, 25
|
Students
present their grant proposals to the class for 'review'
|