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Bio306 SyllabusHaverford CollegeSpring, 2003 |
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Week/Date |
Weekly topics |
Daily Topics |
Assignments |
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1 January 20 |
Fundamental cellular and biochemical themes in signal transduction |
Introduction to signaling and its significance |
Alberts Ch. 15, Part I and Signaling introduction (ELS)
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January 22 |
The three major classes of receptors: fundamentals
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January 24 |
Workshop #1: Signaling and gene regulation
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Assign. #1: On-line assignment due January 31st Science May 31 2002 p. 1632 and How to use STKE, How to use Signaling Gateway |
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2 January 27 |
Analysis of a signaling pathway and experimental approaches |
Introduction to G-protein coupled receptors (the largest family of receptors expressed by animals) Bob Loudon, guest lecturer |
ELS Review of G-protein coupled receptors (GPCR) and Science May 31 issue p. 1636 |
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January 29 |
Introduction to Receptor Tyrosine Kinases (another major group of receptors in animals) |
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January 31 |
Workshop #2: An experimental history of ras | Assign. #2: Designing an experiment due February 5th | |
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3 February 3 |
Signaling and Metabolism |
The b-AR and obesity |
Commentary on b-AR and obesity Science article |
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February 5 |
The insulin receptor and diabetes |
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February 7 |
Workshop #3: Signaling molecules as drug targets | Assign. #3: GPCRs and RTKs as drug targets (a closed book, closed note 'quiz') due February 12th. | |
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4 February 10 |
Signaling and Development |
Apoptosis, caspases, and development (Sam Edmondson, guest lecturer) |
Alberts, Ch. 15, Part IV and STKE Review of proteases and signaling |
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February 12 |
The Wnt pathwy (and autism?) |
ELS Review of Wnt AND Science May 31st issue p. 1644 |
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February 14 |
Workshop#4: Notch and TGFb |
Science May 31st article p. 1646 Assign. #4: Interpreting a primary article due February 19th. |
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5 February 17 |
Signaling outside the animal world |
Bacteria and chemotaxis |
Alberts |
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February 19 |
Plant signaling and the evolutionary implications |
Assign. #5: Signaling and genomics (PSI-BLAST) due February 21st |
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February 21 |
Workshop #5: Final Project - refining your ideas |
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6 February 24 |
Signaling and the Senses |
G-proteins and your sense of smell |
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February 26 |
TRP receptors and temperature sensation |
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February 28 |
Workshop #6: Final Project - developing the project |
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7 March 3 |
Signaling and the Immune System |
Cytokines and inflammation (JAK/STAT) |
ELS Review of JAK/STAT and Science May 31 issue p. 1653 |
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March 5 |
TCR,BCR, synapses and immunodeficiency |
Review on Synapses and Science May 31 issue on TCR signaling p. 1639 |
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March 7 |
Workshop #7 - Final Project: revising, editing and finalizing |
Final project due date to be discussed |
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