Rasmol image of porin complex

BIOLOGY 303 Structure and Function of Proteins

Syllabus (Spring 2011)

Protein structure:
January 19:	The amino acids (amino acid flash cards)
	Branden & Tooze, Chapter 1 (pdf)
	Creighton, pp. 1-20 (pdf)
January 21:	Hierarchy of protein structure and motifs (ppt slides)
	Branden & Tooze, Chapter 2 (pdf)
	Creighton, pp. 182-197, 217-237 (pdf1), (pdf2)
	Harbury et al, 1993 (pdf)
January 24:	Protein structural domains (ppt slides)
	Branden & Tooze, Chapters 3, 4, & 5
January 26:	Analyzing amino acid functionality: case study using ion channel proteins
	(ppt slides)
	Doyle et al, 1998 (pdf)
	MacKinnon Nobel Lecture (pdf)
Advanced protein topics:
January 28:	Translation and the ribosome (the Nobel Prize) (ppt slides)
	Review by Ramakrishnan from Nobel Medal Lecture (pdf)
	Quiz 1 handed out
January 31:	Protein folding and unfolding (in vitro) (ppt slides)
	Branden & Tooze, Chapter 6
	Creighton, pp. 309-323 (pdf)
	a lucid recent review on status of protein folding problem (pdf)
	Due date for Quiz 1
February 2:	Protein folding and unfolding (in vivo)
	Creighton,  pp. 140-162 (pdf)
February 4:	catchup
	Skim Chapter 17 in Branden & Tooze
February 7:	Student presentations
February 9:	Chemical forces defining stability
	Quiz 2 handed out
February 11:	Chemical forces defining stability (cont'd)
February 14:	Student presentations
	Due date for Quiz 2
Enzymes (Branden & Tooze, Chapter 11)
February 16:	Catalysis, allostery, and regulation
February 18:	Molecular mechanisms of serine proteases (ppt slides)
February 21:	Student presentations
DNA regulation (Branden & Tooze, Chapters 8-10)
February 23:	DNA binding motifs
February 25:	Eukaryotic motifs
February 28:	Student presentations
Protein misfolding and disease
December 9:	General principles
	Dobson (2003) Nature, 426:884 (pdf available)
December 11:	Aggregative diseases (Huntington’s, Alzheimer’s, prion disease)