Rasmol image of porin complex

BIOLOGY 303E Structure and Function of Proteins

Syllabus (2009)

Protein structure:
October 26:	The amino acids (amino acid flash cards)
	Branden & Tooze, Chapter 1 (pdf)
	Creighton, pp. 1-20 (pdf)
October 28:	Hierarchy of protein structure and motifs (ppt slides)
	Branden & Tooze, Chapter 2 (pdf)
	Creighton, pp. 182-197, 217-237 (pdf1), (pdf2)
	Harbury et al, 1993 (pdf)
October 30:	Protein structural domains (ppt slides)
	Branden & Tooze, Chapters 3, 4, & 5
November 2:	Analyzing amino acid functionality: case study using ion channel proteins
	(ppt slides)
	Doyle et al, 1998 (pdf)
	MacKinnon Nobel Lecture (pdf)
Advanced protein topics:
November 4:	Translation and the ribosome (the Nobel Prize) (ppt slides)
	Review by Ramakrishnan from Heatley Medal Lecture (pdf available)
	Quiz 1 handed out
November 6:	Protein folding and unfolding (in vitro and in vivo) (ppt slides)
	Branden & Tooze, Chapter 6
	Creighton, pp. 309-323 (pdf)
	Due date for Quiz 1
November 9:	Chemical forces defining stability
	Creighton,  pp. 140-162 (pdf)
November 11:	Catch up Protein design and biomaterials design
	Skim Chapter 17 in Branden & Tooze
November 13	Student presentations
	Quiz 2 handed out
Enzymes (Branden & Tooze, Chapter 11)
November 16:	Catalysis, allostery, and regulation
	Due date for Quiz 2
November 18:	Molecular mechanisms of serine proteases (ppt slides)
November 20:	Student presentations
Proteins of the immune system (Branden & Tooze, Chapter 15)
November 23:	Antibody structure and epitope binding
November 25:	MHC and T-cell receptor
DNA regulation (Branden & Tooze, Chapters 8-10)
November 30:	DNA binding motifs
December 2:	Student presentations
December 4:	Eukaryotic motifs
December 7:	Student presentations
Protein misfolding and disease
December 9:	General principles
	Dobson (2003) Nature, 426:884 (pdf available)
December 11:	Aggregative diseases (Huntington’s, Alzheimer’s, prion disease)