Courses: Senior Research Tutorial in Hematopoietic Stem Cell Biology (BIOLH412A01)
The development and maintenance of vertebrate blood is tasked to rare quiescent multipotent hematopoietic stem cells, which must balance programs for self-renewal and differentiation. This balance is determined both intrinsically through a number of different signaling pathways, including the NF-Y transcription factor, and extrinsically by the microenvironmental niche in which they reside. We employ a combination of cellular and molecular techniques to investigate these two aspects of hematopoietic stem cell regulation. Laboratory work is supplemented with readings from the current literature.
Prerequisites: Consent of instructor.
Fulfills: NA II